Research

New research confirms that the euphoria of intense exercise is driven primarily by the body's own cannabinoid system, rewriting a decades-old assumption about endorphins.

A controlled trial at Johns Hopkins found that specific terpene profiles changed the subjective experience and neurological response to THC, lending scientific weight to a long-debated cannabis theory.

Published in JAMA Internal Medicine, the retrospective study of 15,000 veterans across 12 states found significant and sustained reductions in opioid use after medical cannabis enrollment.

The review analyzed 50 randomized controlled trials and found that cannabinoids may reduce chronic pain intensity by a small but meaningful amount — while flagging high rates of adverse events.

Published in The Lancet Psychiatry, the systematic review examined hundreds of studies and found insufficient evidence to support therapeutic claims for cannabinoid treatments of mental health conditions.